(2005) identified an MSе…ѓ splice variant that encodes a deduced 355-amino acid isoform lacking the N-terminal chromodomain of full-length MSе…ѓL1. (1999) showed that the MSе…ѓL1 gene undergoes X inactivation.Д«y database analysis, Smith et al. Northern blot analysis of E7, E11, E15, and E17 mouse embryos detected approximately equal levels of Msl3l1 expression in all embryos. A 2.6-kb transcript unique to skeletal muscle was also found. Northern blot analysis detected a major 2.4-kb MSе…ѓL1 transcript in all tissues examined, namely liver, pancreas, heart, lung, kidney, skeletal muscle, brain, and placenta, with highest expression in skeletal muscle and heart. The predicted protein, which the authors referred to as isoform 2, is identical to the first isoform from amino acid 62 to the C terminus but does not contain the first 26 amino acids of the N-terminal chromodomain. (1999) identified human fetal kidney cDNAs representing an alternatively spliced MSе…ѓL1 transcript that lacks exon 2.

MSе…ѓL1 also contains a putative nuclear localization signal, a putative leucine zipper motif within the second chromodomain, and 2 potential tyrosine kinase phosphorylation sites. Chromodomains, which form a characteristic tertiary structure and can interact with components of chromatin, have been implicated to play roles in chromatin organization and transcriptional regulation.

Three segments of the Drosophila MSе…ѓ protein are highly conserved in MSе…ѓL1, including 2 putative chromodomains, 1 at the N terminus and the other at the C terminus. The deduced 521-amino acid MSе…ѓL1 protein shares 30% overall sequence identity with Drosophila MSе…ѓ and 86% identity with mouse Msl3l1, which the authors also identified. They isolated a cDNA containing a complete MSе…ѓL1 coding sequence. (1999) identified a human homolog of Drosophila male-specific lethal-3, MSе…ѓ-like-1 (MSе…ѓL1). By searching sequence databases with the sequence of a BAC clone that maps to Xp22.3, Prakash et al.

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